PUREVAX: Benefits

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Benefits of Recombinant Vaccines
Recombinant vaccines like PUREVAX^® Recombinant Leukemia Vaccine offer many advantages over traditional vaccines.

Not all vaccines are alike.

Killed Vaccines

Pros

Safe in immunosuppressed animals¹
Will not revert to virulence¹

Cons

Increased risk of allergic complications¹
More hypersensitivity reactions (local and systemic¹)
Adjuvanted
- Risk of injection-site granuloma²
High antigen concentration¹

RECOMBINANT

PUREVAX^® Recombinant Leukemia Vaccine

Pros
Safety

No pathogenic virus present in vaccine
No risk of reversion to virulence
No adjuvants (No adjuvants for Feline vaccines)
No needles³
Low-volume dose @ 0.25 mL⁴

Immunogenicity

Induces cell-mediated immunity⁵
Induces humoral (antibody) response
Expresses protein antigens in natural form⁵

Targeted Immune Response

Enhances activation of B- and T-lymphocytes⁵
Immunizes against the critical viral proteins needed for protection only:
- nucleocapsid⁶
- envelope⁷

MODIFIED LIVE VIRUS

MLV Vaccines

Pros

Induces cell-mediated immunity¹
Induces humoral (antibody) response¹
Non-adjuvanted (Typically non-adjuvanted)
Vaccine virus replicates in host: lower virus (antigen) load¹
Rapid protection¹
Lower antigen mass needed¹

Cons

Vaccine virus replicates in host:
- May revert to virulent virus (rare)¹
Potential shedding of vaccine virus
May produce vaccine-induced illness¹
Not recommended for immunosuppressed animals¹

^{¹Green CE. Immunoprophylaxis and immunotherapy. In: Greene CE, ed. Infectious Diseases of the Dog and Cat. Philadelphia:WB Saunders Co, 1998:721.

²Macy DW, Hendrick MJ. The Potential role of inflammation in the development of postvaccinal sarcomas in cats. Vet Clin North Am Small Animal Prac 1996;26(1)103-109.

³Only PUREVAX Recombinant Leukemia Vaccine

⁴PUREVAX Recombinant Leukemia Vaccine delivered only transdermally with the
VET JET transdermal vaccination system

⁵Data on file.

⁶nucleocapsid (p.27)

⁷envelope (p.70)}

For more detailed information on the immunogenic properties of canarypox vectored vaccines, click here.

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